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49844-90-8 - 4-Chloro-2-(methylthio)pyrimidine, 98% - 4-Chloro-2-(methylmercapto)pyrimidine - B21481 - Alfa Aesar

B21481 4-Chloro-2-(methylthio)pyrimidine, 98%

CAS 번호
49844-90-8
동의어
4-Chloro-2-(methylmercapto)pyrimidine

사이즈 가격 ($) 수량 재고 여부
10g 61.80
50g 252.00
250g 1133.00
장바구니에 추가 대량 견적에 추가 항목 보기

4-Chloro-2-(methylthio)pyrimidine, 98%

MDL
MFCD00006083
EINECS
256-500-6

화학적 특성

화학식
C5H5ClN2S
화학 식량
160.63
융점
ca -2°
비등점
118-120°/9mm
인화점
>110°(230°F)
밀도
1.380
굴절률
1.6 00
감도
Moisture Sensitive
용해도
Not miscible or difficult to mix in water.

용도

It finds it application as a building block used in medicinal chemistry synthesis. 4-Chloro-2-methylthiopyrimidine is used in the total synthesis of the marine alkaloid variolin B1 and 2-hydroxy-4-pyrimidinecarboxylic acid. It is also used in the synthesis of 2,4-disubstituted pyrimidines, a novel class of KDR kinase inhibitors.

참고

Moisture sensitive. Store away from oxidizing agents, bases, water/moisture, heat and light. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Keep it refrigerated.

참조 문헌

Daves GD, et al. Pyrimidines. XIII. 2-and 6-substituted 4-pyrimidinecarboxylic acids.J. Heterocycl. Chem.19641(3), 130-133.

Peter J Manley, et al. 2,4-disubstituted pyrimidines: a novel class of KDR kinase inhibitors.Bioorg. Med. Chem. Lett.200313(10), 1673-1677.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

주의 설명서: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a

Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

바일슈타인
118042
위험 등급
8
포장 그룹
III
통합 관세 코드
2933.59
TSCA(독성물질규제법)"
No

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