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A GABAc antagonistImidazole-4-acetic acid monohydrochloride is used in the preparation of imidazolyl-polyethylenimine modified nanoparticles. It is also used to prepare pyridyl and imidazoyl functionalized carboproteins and potential metal ion chelators. Further, it acts as an imidazole derivative with potential antituberculousis properties. In addition to this, it is used in the generation of acyl guanidine inhibitors of beta-secretas.
Hayallah, A. M. Design and Synthesis of New (SecinH3) Derivatives as Potential Cytohesin Inhibitors. Indian. J. Pharm. Sci. 2014, 76 (5), 387-400.
Matsuo, K.; Kioi, Y.; Yasui, R.; Takaoka, Y.; Miki, T.; Fujishima, S. H.; Hamachi, I. One-step construction of caged carbonic anhydrase I using a ligand-directed acyl imidazole-based protein labeling method. Chem. Sci. 2013, 4 (6), 2573-2580.
Goyal, R.; Bansal, R.; Tyagi, S.; Shukla, Y.; Kumar, P.; Gupta, K. C. 1,4-Butanediol diglycidyl ether (BDE)-crosslinked PEI-g-imidazole nanoparticles as nucleic acid-carriers in vitro and in vivo. Mol. BioSyst. 2011, 7 (6), 2055-2065.