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3699-66-9 - Triethyl 2-phosphonopropionate, 98% - Diethyl 1-(ethoxycarbonyl)ethanephosphonate - 2-Phosphonopropionic acid triethyl ester - B23261 - Alfa Aesar

B23261 Triethyl 2-phosphonopropionate, 98%

CAS 번호
3699-66-9
동의어
Diethyl 1-(ethoxycarbonyl)ethanephosphonate
2-Phosphonopropionic acid triethyl ester

사이즈 가격 ($) 수량 재고 여부
10g 36.40
50g 109.00
장바구니에 추가 대량 견적에 추가 항목 보기

Triethyl 2-phosphonopropionate, 98%

MDL
MFCD00009159
EINECS
223-033-4

화학적 특성

화학식
C9H19O5P
화학 식량
238.22
비등점
143-144°/12mm
인화점
88°(190°F)
밀도
1.111
굴절률
1.4320
용해도
Miscible with chloroform and methanol.

용도

Triethyl 2-phosphonopropionate is used as a reactant in intramolecular conjugate addition for the synthesis of floresolide B, enantioselective synthesis of spiroindane di-methyl acetic acid and in stereo selective intramolecular Diels-Alder reactions. It plays an important role in Horner-Wadsworth-Emmons reactions and chemoenzymatic one-pot synthesis of gamma-butyrolactones. It is also used in the preparation of 3-[2]furyl-2-methyl-acrylic acid ethyl ester by reacting with furfural.

참고

Incompatible with strong bases.

참조 문헌

Wadsworth-Emmons precursor of methacrylic esters (see Triethyl­ phosphonoacetate, A14120 and Appendix 1). Lithiation followed by acylation with perfluoroalkanoic anhydrides gives a perfluoroacyl intermediate which, with an organolithium reagent, leads stereoselectively to a trifluoroalkylated ɑß-unsaturated ester: J. Fluorine Chem., 89, 141 (1998):

Sharpe, M. A.; Han, J.; Baskin, A. M.; Baskin, D. S. Design and Synthesis of a MAO-B-Selectively Activated Prodrug Based on MPTP: A Mitochondria-Targeting Chemotherapeutic Agent for Treatment of Human Malignant Gliomas. ChemMedChem 2015, 10 (4), 621-628.

Shouksmith, A. E.; Evans, L. E.; Tweddle, D. A.; Miller, D. C.; Willmore, E.; Newell, D. R.; Golding, B. T.; Griffin, R. J. Synthesis and Activity of Putative Small-molecule Inhibitors of the F-box Protein SKP2. Aust. J. Chem. 2015, 68 (4), 660-679.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H227

Combustible liquid.

주의 설명서: P210u-P280a-P370+P378a-P403+P235-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wear protective gloves and eye/face protection. In case of fire: Use for extinction: CO2, powder or water spray. Store in a well-ventilated place. Keep cool. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

바일슈타인
1786994
통합 관세 코드
2931.39
TSCA(독성물질규제법)"
No

권장

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    Boron trifluoride diethyl etherate, 98+%
  • 31721

    Methanol, ACS, absolute, low acetone, 99.8+%

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