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103-74-2 - 2-(2-Hydroxyethyl)pyridine, 99% - 2-Pyridineethanol - 2-(2-Pyridyl)ethanol - B23579 - Alfa Aesar

B23579 2-(2-Hydroxyethyl)pyridine, 99%

CAS 번호
103-74-2
동의어
2-Pyridineethanol
2-(2-Pyridyl)ethanol

사이즈 가격 ($) 수량 재고 여부
100g 27.20
500g 85.20
장바구니에 추가 대량 견적에 추가 항목 보기

2-(2-Hydroxyethyl)pyridine, 99%

MDL
MFCD00006364
EINECS
203-140-2

화학적 특성

화학식
C7H9NO
화학 식량
123.16
융점
-8°
비등점
235-238°
인화점
117°(243°F)
밀도
1.095
굴절률
1.5370
감도
Hygroscopic
용해도
Soluble in Chloroform (Slightly), Methanol (Slightly).

용도

2-(2-Hydroxyethyl)pyridine is a metabolite of the anti-vertigo drug Betahistine. It acts as a reagent for protection of the 5'-phosphate of nucleotides as 2-pyridylethyl (Pet) esters. It is used for carboxyl protection of amino acids. It is also used to cleave such groups as Boc and Fmoc, and also to hydrogenolysis. It was used to prepare mononuclear nickel(II) acetate.

참고

Hygroscopic. Store under dry inert gas. Store away from moisture, strong bases and oxidizing agents. Protect from humidity and water.

참조 문헌

Miha Trdin; Valter Bergant; Ivan Leban; Nina Lah. Two concomitant polymorphs of monomeric nickel acetate with 2-pyridineethanol. Acta Chimica Slovenica. 2012, 59, (3), 478-483.

Takashi Niwa; Hideki Yorimitsu; Koichiro Oshima. Palladium-Catalyzed 2-Pyridylmethyl Transfer from 2-(2-Pyridyl)ethanol Derivatives to Organic Halides by Chelation-Assisted Cleavage of Unstrained Cmath image[BOND]Cmath image Bonds. Angewandte Chemie (International Edition). 2007, 46, (15), 2643-2645.

Reagent for protection of the 5'-phosphate of nucleotides as 2-pyridylethyl (Pet) esters. The group can be introduced by DCC-coupling, is stable to mild base, but can be cleaved by methoxide in pyridine-methanol: Chem. Ber., 103, 1032 (1970).

Has also been used for carboxyl protection of amino acids. Pet esters are stable to both mildly acidic and basic conditions used to cleave such groups as Boc and Fmoc, and also to hydrogenolysis. Cleavage is by quaternization with methyl iodide in the presence of mild base: Tetrahedron Lett., 25, 3971 (1984); Angew. Chem. Int. Ed., 23, 716 (1984). See Appendix 6.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H227-H315-H319-H335

Combustible liquid. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

주의 설명서: P210u-P261-P280a-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

바일슈타인
111205
통합 관세 코드
2933.39
TSCA(독성물질규제법)"
Yes
RTECS(화학물질 독성 등록)
UT2970450

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