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942-01-8 - 1,2,3,4-Tetrahydrocarbazole, 99% - B23657 - Alfa Aesar

B23657 1,2,3,4-Tetrahydrocarbazole, 99%

CAS 번호
942-01-8
동의어

사이즈 가격 ($) 수량 재고 여부
25g 38.60
100g 103.00
장바구니에 추가 대량 견적에 추가 항목 보기

1,2,3,4-Tetrahydrocarbazole, 99%

MDL
MFCD00004959
EINECS
213-385-7

화학적 특성

화학식
C12H13N
화학 식량
171.24
융점
118-120°
비등점
325-330°
용해도
Insoluble in water. Solubility in methanol (almost transparency).

용도

It finds its application as a pharmaceutical intermediate and in the synthesis of aspidospermidine alkaloids.

참고

Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

참조 문헌

Crosby U. Rogers and B. B. Corson. One-Step Synthesis of 1,2,3,4-Tetrahydrocarbazole and 1,2-Benzo-3,4-dihydrocarbazole.J. Am. Chem. Soc.,1947,69(11), 2910-2911.

Anahí Urrutia, et. al. Synthesis of aspidospermidine alkaloids from 1,2,3,4-tetrahydrocarbazole: Total stereoselective synthesis of (±)-18-noraspidospermidine.Tetrahedron.,2014,55(36), 11095-11108.

Deprotonation with excess superbasic n-BuLi/KO-t-Bu to give the N,ɑ-dianion has been studied in a variety of ether solvents. Formation of substantial amounts of the ɑ-ethyl derivative was observed with Et2O and THF, and also, remarkably, with various alkyl methyl ethers; e.g. in n-BuOMe, the ɑ-ethyl product was obtained in 60% yield. The ethyl group originates from the interaction of the solvent with the strong base, confirmed by the detection of ethylene in the absence of the tetrahydrocarbazole substrate: J. Org. Chem., 60, 8334 (1995). ɑ-Ethylation also occurred with 2-ethylindole, but not with 2-methyl- or 2-isopropyl analogues.

Photooxygenation with singlet oxygen, followed by reduction of the expected hydroperoxide to the allylic alcohol, is accompanied by ring contraction to a spiro ketone. The same product is formed in high yield on treatment of the spiroketone with mineral acid: J. Org. Chem., 61, 810 (1996):

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H303-H315-H319-H335

May be harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

주의 설명서: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

바일슈타인
133771
통합 관세 코드
2933.99
TSCA(독성물질규제법)"
No
RTECS(화학물질 독성 등록)
FE6300000

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