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128625-52-5 - 1H-Benzotriazol-1-yloxytri(1-pyrrolidinyl)phosphonium hexafluorophosphate, 98% - B25251 - Alfa Aesar

B25251 1H-Benzotriazol-1-yloxytri(1-pyrrolidinyl)phosphonium hexafluorophosphate, 98%

CAS 번호
128625-52-5
동의어

사이즈 가격 ($) 수량 재고 여부
5g 70.20
25g 270.00
장바구니에 추가 대량 견적에 추가 항목 보기

1H-Benzotriazol-1-yloxytri(1-pyrrolidinyl)phosphonium hexafluorophosphate, 98%

MDL
MFCD00077411
EINECS
000-000-0

화학적 특성

화학식
C18H28F6N6OP2
화학 식량
520.40
융점
ca 155° dec.
감도
Moisture Sensitive
용해도
Soluble in chloroform.

용도

1H-Benzotriazol-1-yloxytri(1-pyrrolidinyl) phosphonium hexafluorophosphate is a peptide coupling reagent utilized in solid phase peptide synthesis. It is also used as a substitute for the (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent.

참고

Store in a cool place. Incompatible with oxidizing agents and water.

참조 문헌

Low racemization peptide coupling reagent (see Appendix 6), introduced by Castro, analogous to BOP Reagent (1H-Benzotriazol-1-yl­oxytris(dimethyl­amino)­phosphonium hexafluorophosphate, A16140) but avoiding the formation of the carcinogenic HMPA as a by-product: Tetrahedron Lett., 31, 205 (1990). For use in formation of mixed phosphonate diesters, see: J. Org. Chem., 60, 5214 (1995).

Cagide, F.; Silva, T.; Reis, J.; Gaspar, A.; Borges, F.; Gomes, L. R.; Low, J. N. Discovery of two new classes of potent monoamine oxidase-B inhibitors by tricky chemistry. Chem. Commun. 2015, 51 (14), 2832-2835.

Raibaut, L.; Drobecq, H.; Melnyk, O. Selectively Activatable Latent Thiol and Selenolesters Simplify the Access to Cyclic or Branched Peptide Scaffolds. Org. Lett. 2015, 17 (14), 3636-3639.

GHS 해저드 및 주의 설명서

해저드 설명서 (EU): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

주의 설명서: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

기타 참조

바일슈타인
3584612
통합 관세 코드
2933.99
TSCA(독성물질규제법)"
No

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