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618-27-9 - cis-4-Hydroxy-L-proline, 99% - (2S,4S)-(-)-4-Hydroxypyrrolidine-2-carboxylic acid - H-cis-Hyp-OH - H27194 - Alfa Aesar

H27194 cis-4-Hydroxy-L-proline, 99%

CAS 번호
618-27-9
동의어
(2S,4S)-(-)-4-Hydroxypyrrolidine-2-carboxylic acid
H-cis-Hyp-OH

사이즈 가격 ($) 수량 재고 여부
250mg 166.00
1g 522.00
장바구니에 추가 대량 견적에 추가 항목 보기

cis-4-Hydroxy-L-proline, 99%

MDL
MFCD00064319
EINECS
210-542-1

화학적 특성

화학식
C5H9NO3
화학 식량
131.13
융점
ca 250° dec.
용해도
Soluble in water.

용도

cis-4-Hydroxy-L-proline (CHP) is a proline analog that inhibits collagen synthesis and has been used as an anticancer compound. CHP blocked myotube formation and expression of sarcomeric myosin heavy chain in C2C12 murine skeletal muscle cells. CHP inhibited proliferation of murine Panc02 pancreatic carcinoma cell line3 and rat pancreatic carcinoma cell line DSL6A. cis-4-Hydroxy-L-proline and other hydrosyl-L-prolines are important intermediates for chiral synthesis of potential drugs.

참고

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

참조 문헌

Heather Dickens et. al. Anticancer drug cis-4-hydroxy-L-proline: Correlation of preclinical toxicology with clinical parameters of liver function. Molecular Medicine Reports. 2008, 1(4), 459-464 .

Roux A, Xu Y,; Heilier JF,; Olivier MF,; Ezan E,; Tabet JC,; Junot C. Annotation of the human adult urinary metabolome and metabolite identification using ultra high performance liquid chromatography coupled to a linear quadrupole ion trap-Orbitrap mass spectrometer. Analytical chemistry. 2012, 84 6429-6437.

기타 참조

통합 관세 코드
2933.99
TSCA(독성물질규제법)"
Yes

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