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L-Homophenylalanine is used as a precursor in the pharmaceutical industry for the production of angiotensin-converting enzyme (ACE) and R-(-)-Homophenylalanin-ethylester. It is also involved in the synthesis of NEPA [(S,S)-N-(1-Ethoxycarbonyl-3-phenylpropyl)alanine], which is a key intermediate to prepare the ACE-inhibitors: enalapril, delapril, quinapril and ramipril. It acts as an anti-tumor reagent.
Zhang, J.; Tao, S.; Zhang, B.; Wu, X.; Chen, Y. Microparticle-based strategy for controlled release of substrate for the biocatalytic preparation of L-homophenylalanine. ACS Catal. 2014, 4 (5), 1584-1587.
Zhang, J.; Zhu, T.; Wu, X.; Chen, Y. Enhancement of biocatalytic efficiency by increasing substrate loading: enzymatic preparation of L-homophenylalanine. Appl. Microbiol. Biotechnol. 2013, 97 (19), 8487-8494.