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A convergent synthesis of the proposed structure of (+)-pestalazine B has been achieved in 4 steps using the N-alkylation of an unprotected tryptophan diketopiperazine with a 3a-bromopyrrolidinoindoline where the condensation between L-tryptophan methyl ester and N-Fmoc-D-leucine in the presence of EDC as coupling agent afforded the corresponding L-Trp-D-Leu dipeptide.
Carlos Pérez-Baladoa,; Ángel R. de Lera. Concise total synthesis and structural revision of (+)-pestalazine B. Org. Biomol. Chem. 2010, 8 5179-5186.
Zhimou Yang et. al. Self-assembly of small molecules affords multifunctional supramolecular hydrogels for topically treating simulated uranium wounds. Chemical Communications. 2005, 35 4414-4416 .