The 10-chloro-8-fluoro-10, 11-dihydro-2-trifluoromethyldibenzothiepin used as the starting material can be prepared starting from 2-iodo--4-trifluoromethyl-benzoic acid and 4-fluoro-thiophenol.
Pascual Segura,; Joseph F. Bunnett,; Laura Villanova. Substituent effects on the decarboxylation of dinitrobenzoate ions. Representative aromatic SE1 reactions. J. Org. Chem. 1985, 50 (7), 1041-1045.
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해저드 설명서 (EU): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
주의 설명서: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.